Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage

doi:10.1293/tox.2013-0053

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/99704

請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/99704

題名:	Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
作者:	Cheng, Chien-Chung;Chou, Chi-Yuan;Chang, Yao-Chin;Wang, Hsuan-Wen;Wen, Chi-Chung;Chen, Yau-Hung
貢獻者:	淡江大學數學學系;淡江大學化學學系
關鍵詞:	comfrey;fin;UV;zebrafish
日期:	2014-07-01
上傳時間:	2014-12-11 09:19:01 (UTC+8)
出版者:	Japanese Society of Toxicologic Pathology,Nihon Dokusei Byoori Gakkai
摘要:	In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes. Chemopreventive effects of comfrey leave extracts were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean times of return to normal fin in the UV+comfrey (50 and 100 ppm) groups were 3.43 and 2.86 days and were quicker compared with that in the UV only group (4.21 days); (2) zebrafish fins in the UV+comfrey (50 and 100 ppm) groups were 2.05 and 3.25 times more likely to return to normal than those in the UV only group; and (3) comfrey leave extracts had UV-absorbance abilities and significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, comfrey leaves extracts may have the potential to be developed as UV-protective agents to protect zebrafish embryos from UV-induced damage.
關聯:	Journal of Toxicologic Pathology 27(2), pp.115-121
DOI:	10.1293/tox.2013-0053
顯示於類別:	[化學學系暨研究所] 期刊論文 [數學學系暨研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
27_2013-0053.pdf		1503Kb	Adobe PDF	271	檢視/開啟
index.html		0Kb	HTML	190	檢視/開啟

在機構典藏中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....