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    題名: Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
    作者: Cheng, Chien-Chung;Chou, Chi-Yuan;Chang, Yao-Chin;Wang, Hsuan-Wen;Wen, Chi-Chung;Chen, Yau-Hung
    貢獻者: 淡江大學數學學系;淡江大學化學學系
    關鍵詞: comfrey;fin;UV;zebrafish
    日期: 2014-07-01
    上傳時間: 2014-12-11 09:19:01 (UTC+8)
    出版者: Japanese Society of Toxicologic Pathology,Nihon Dokusei Byoori Gakkai
    摘要: In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes. Chemopreventive effects of comfrey leave extracts were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean times of return to normal fin in the UV+comfrey (50 and 100 ppm) groups were 3.43 and 2.86 days and were quicker compared with that in the UV only group (4.21 days); (2) zebrafish fins in the UV+comfrey (50 and 100 ppm) groups were 2.05 and 3.25 times more likely to return to normal than those in the UV only group; and (3) comfrey leave extracts had UV-absorbance abilities and significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, comfrey leaves extracts may have the potential to be developed as UV-protective agents to protect zebrafish embryos from UV-induced damage.
    關聯: Journal of Toxicologic Pathology 27(2), pp.115-121
    DOI: 10.1293/tox.2013-0053
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