Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data

doi:10.1007/978-3-319-13186-3_67

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题名:	Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
作者:	Weng, Julia Tzu-Ya;Chen, Yi-Cheng;Chang, Pei-Chann;Huang, Shin-Ping;Chiu, Yu-Wei
贡献者:	淡江大學資訊工程學系
关键词:	cardiomyocytes;regeneration;3-D culture system;gene expression;bioinformatics
日期:	2014-05-13
上传时间:	2014-11-30 13:14:42 (UTC+8)
出版者:	Springner
摘要:	Cardiovascular diseases are the leading cause of death worldwide. Loss or dysfunction of cardiomyocytes is associated with many forms of heart disease. The adult mammalian heart has a limited regenerative ability after damage, leading to the formation of fibrotic scar tissues, hypertrophy, contractile dysfunction and ul-timately, organ failure. In contrast, neonatal mammalian cardiomyocytes retain a significant replenishing potential briefly after birth. There is increasing enthusiasm to grow neonatal cardiomyocytes in 3D culture systems to artificially restore heart function. Various scaffolds and matrices are available, but the molecular and cellu-lar mechanisms underlying proliferation and differentiation of neonatal mammalian cardiomyocytes are not very well understood. Here, we utilize a systematic strategy to analyze the extensive genome-scale gene expression profiles of two different 3D constructs. We present a comprehensive comparison that may help improve the protocols for growing cardiomyocytes in a 3D culture system.
關聯:	Lecture Notes in Artificial Intelligence 8643, pp.754-764
DOI:	10.1007/978-3-319-13186-3_67
显示于类别:	[資訊工程學系暨研究所] 會議論文

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