English  |  正體中文  |  简体中文  |  Items with full text/Total items : 51275/86342 (59%)
Visitors : 8146817      Online Users : 60
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/99574


    Title: Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
    Authors: Weng, Julia Tzu-Ya;Chen, Yi-Cheng;Chang, Pei-Chann;Huang, Shin-Ping;Chiu, Yu-Wei
    Contributors: 淡江大學資訊工程學系
    Keywords: cardiomyocytes;regeneration;3-D culture system;gene expression;bioinformatics
    Date: 2014-05-13
    Issue Date: 2014-11-30 13:14:42 (UTC+8)
    Publisher: Springner
    Abstract: Cardiovascular diseases are the leading cause of death worldwide. Loss or dysfunction of cardiomyocytes is associated with many forms of heart disease. The adult mammalian heart has a limited regenerative ability after damage, leading to the formation of fibrotic scar tissues, hypertrophy, contractile dysfunction and ul-timately, organ failure. In contrast, neonatal mammalian cardiomyocytes retain a significant replenishing potential briefly after birth. There is increasing enthusiasm to grow neonatal cardiomyocytes in 3D culture systems to artificially restore heart function. Various scaffolds and matrices are available, but the molecular and cellu-lar mechanisms underlying proliferation and differentiation of neonatal mammalian cardiomyocytes are not very well understood. Here, we utilize a systematic strategy to analyze the extensive genome-scale gene expression profiles of two different 3D constructs. We present a comprehensive comparison that may help improve the protocols for growing cardiomyocytes in a 3D culture system.
    Relation: Lecture Notes in Artificial Intelligence 8643, pp.754-764
    DOI: 10.1007/978-3-319-13186-3_67
    Appears in Collections:[資訊工程學系暨研究所] 會議論文

    Files in This Item:

    File Description SizeFormat
    2014_Comparative analysis of 3D-culture system for murine neonatal heart regeneration a systematic approach for big gene expression data.pdf1528KbAdobe PDF213View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback