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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/99574

    Title: Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
    Authors: Weng, Julia Tzu-Ya;Chen, Yi-Cheng;Chang, Pei-Chann;Huang, Shin-Ping;Chiu, Yu-Wei
    Contributors: 淡江大學資訊工程學系
    Keywords: cardiomyocytes;regeneration;3-D culture system;gene expression;bioinformatics
    Date: 2014-05-13
    Issue Date: 2014-11-30 13:14:42 (UTC+8)
    Publisher: Springner
    Abstract: Cardiovascular diseases are the leading cause of death worldwide. Loss or dysfunction of cardiomyocytes is associated with many forms of heart disease. The adult mammalian heart has a limited regenerative ability after damage, leading to the formation of fibrotic scar tissues, hypertrophy, contractile dysfunction and ul-timately, organ failure. In contrast, neonatal mammalian cardiomyocytes retain a significant replenishing potential briefly after birth. There is increasing enthusiasm to grow neonatal cardiomyocytes in 3D culture systems to artificially restore heart function. Various scaffolds and matrices are available, but the molecular and cellu-lar mechanisms underlying proliferation and differentiation of neonatal mammalian cardiomyocytes are not very well understood. Here, we utilize a systematic strategy to analyze the extensive genome-scale gene expression profiles of two different 3D constructs. We present a comprehensive comparison that may help improve the protocols for growing cardiomyocytes in a 3D culture system.
    Relation: Lecture Notes in Artificial Intelligence 8643, pp.754-764
    DOI: 10.1007/978-3-319-13186-3_67
    Appears in Collections:[資訊工程學系暨研究所] 會議論文

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