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    題名: MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure
    作者: Lee, Kuei-Fang;Chen, Yi-Cheng;Hsu, Paul Wei-Che;Liu, Ingrid Y.;Wu, Lawrence Shih-Hsin
    貢獻者: 淡江大學資訊工程學系
    日期: 2014-08-16
    上傳時間: 2014-09-18 00:23:15 (UTC+8)
    出版者: New York: Hindawi Publishing Corporation
    摘要: Various biological effects are associated with radiation exposure. Irradiated cells may elevate the risk for genetic instability, mutation, and cancer under low levels of radiation exposure, in addition to being able to extend the postradiation side effects in normal tissues. Radiation-induced bystander effect (RIBE) is the focus of rigorous research as it may promote the development of cancer even at low radiation doses. Alterations in the DNA sequence could not explain these biological effects of radiation and it is thought that epigenetics factors may be involved. Indeed, some microRNAs (or miRNAs) have been found to correlate radiation-induced damages and may be potential biomarkers for the various biological effects caused by different levels of radiation exposure. However, the regulatory role that miRNA plays in this aspect remains elusive. In this study, we profiled the expression changes in miRNA under fractionated radiation exposure in human peripheral blood mononuclear cells. By utilizing publicly available microRNA knowledge bases and performing cross validations with our previous gene expression profiling under the same radiation condition, we identified various miRNA-gene interactions specific to different doses of radiation treatment, providing new insights for the molecular underpinnings of radiation injury.
    關聯: BioMed Research International 2014, 456323(10pages)
    DOI: 10.1155/2014/456323
    顯示於類別:[資訊工程學系暨研究所] 期刊論文

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