Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure

doi:10.1155/2014/834087

機構典藏 > College of Engineering > Graduate Institute & Department of Computer Science and Information Engineering > Journal Article > Item 987654321/98679

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Title:	Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
Authors:	Lee, Kuei-Fang;Weng, Julia Tzu-Ya;Hsu, Paul Wei-Che;Chi, Yu-Hsiang;Chen, Ching-Kai;Liu, Ingrid Y.;Chen, Yi-Cheng;Wu, Lawrence Shih-Hsin
Contributors:	淡江大學資訊工程學系
Date:	2014-07-21
Issue Date:	2014-09-10 01:26:04 (UTC+8)
Publisher:	New York: Hindawi Publishing Corporation
Abstract:	Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling. Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure. Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage. In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations. Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
Relation:	BioMed Research International 2014, 834087(9 pages)
DOI:	10.1155/2014/834087
Appears in Collections:	[Graduate Institute & Department of Computer Science and Information Engineering] Journal Article

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