Dynamic Structural Transformation of Resveratrol-Modified Stearate Liposomes Led to a Spontaneous Drug Release System

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Title:	Dynamic Structural Transformation of Resveratrol-Modified Stearate Liposomes Led to a Spontaneous Drug Release System
Authors:	Chen, Li-Chou;Lin, Shih-Shan;Li, Cun-Zhao;Hsu, Hsiu-Fu;Weng, Yu-Jong;Cheng, Chien-Chung
Contributors:	淡江大學化學學系
Keywords:	Liposome;Resveratrol;Stearate;Helical transformation;Drug-release
Date:	2014-09
Issue Date:	2014-08-09 16:18:28 (UTC+8)
Publisher:	Oxford: Wiley-Blackwell Publishing Ltd.
Abstract:	A mono-substituted resveratrol derivative, resveratrol-modified stearate (RMS), was synthesized by selectively coupling of stearic acid to the monohroxyphenyl of resveratrol in order to enhance both the stability and bioavailability of resveratrol. The RMS self-assembles into liposomes and a series of suprastructural transformations into metastable helical ribbon, linear wire-like structures, and inert spherical nanoparticles were detected that may be induced by the hydrogen-bonding interactions. As a model for drug-release investigations, gold nanoparticles (AuNPs) were encapsulated successfully by RMS to generate vesicles and succeed to release AuNPs druing the transformation to a ribbon-like metastable stucture at ambient temperature.
Relation:	Journal of the Chinese Chemical Society 60(9), pp.1099-1102
DOI:	10.1002/jccs.201300184
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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