Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/98496

請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/98496

題名:	Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
作者:	Lian, Ru-Ching;Lin, Meng-Hsuan;Liao, Pin-Hsuan;Fu, Jia-Jie;Wu, Meng-Ju;Wu, Yang-Chang;Chang, Fang-Rong;Wu, Chin-Chung;Pan, Po-Shen
貢獻者:	淡江大學化學學系
關鍵詞:	Boronic acids;Ugi-4CR;Multicomponent reaction;Microwave-assisted synthesis;Acid/base extraction
日期:	2014-03-04
上傳時間:	2014-08-08 14:31:54 (UTC+8)
出版者:	Pergamon Press
摘要:	A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
關聯:	Tetrahedron 70(9), pp.1800–1804
DOI:	10.1016/j.tet.2014.01.016
顯示於類別:	[化學學系暨研究所] 期刊論文

文件中的檔案:

檔案	描述	大小	格式	瀏覽次數
Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction.pdf		378Kb	Adobe PDF	2	檢視/開啟
index.html		0Kb	HTML	154	檢視/開啟

在機構典藏中所有的資料項目都受到原著作權保護.

TAIR相關文章