Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/98496

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题名:	Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
作者:	Lian, Ru-Ching;Lin, Meng-Hsuan;Liao, Pin-Hsuan;Fu, Jia-Jie;Wu, Meng-Ju;Wu, Yang-Chang;Chang, Fang-Rong;Wu, Chin-Chung;Pan, Po-Shen
贡献者:	淡江大學化學學系
关键词:	Boronic acids;Ugi-4CR;Multicomponent reaction;Microwave-assisted synthesis;Acid/base extraction
日期:	2014-03-04
上传时间:	2014-08-08 14:31:54 (UTC+8)
出版者:	Pergamon Press
摘要:	A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
關聯:	Tetrahedron 70(9), pp.1800–1804
DOI:	10.1016/j.tet.2014.01.016
显示于类别:	[化學學系暨研究所] 期刊論文

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