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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/98496

    Title: Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
    Authors: Lian, Ru-Ching;Lin, Meng-Hsuan;Liao, Pin-Hsuan;Fu, Jia-Jie;Wu, Meng-Ju;Wu, Yang-Chang;Chang, Fang-Rong;Wu, Chin-Chung;Pan, Po-Shen
    Contributors: 淡江大學化學學系
    Keywords: Boronic acids;Ugi-4CR;Multicomponent reaction;Microwave-assisted synthesis;Acid/base extraction
    Date: 2014-03-04
    Issue Date: 2014-08-08 14:31:54 (UTC+8)
    Publisher: Pergamon Press
    Abstract: A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
    Relation: Tetrahedron 70(9), pp.1800–1804
    DOI: 10.1016/j.tet.2014.01.016
    Appears in Collections:[化學學系暨研究所] 期刊論文

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