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    题名: Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
    作者: Lian, Ru-Ching;Lin, Meng-Hsuan;Liao, Pin-Hsuan;Fu, Jia-Jie;Wu, Meng-Ju;Wu, Yang-Chang;Chang, Fang-Rong;Wu, Chin-Chung;Pan, Po-Shen
    贡献者: 淡江大學化學學系
    关键词: Boronic acids;Ugi-4CR;Multicomponent reaction;Microwave-assisted synthesis;Acid/base extraction
    日期: 2014-03-04
    上传时间: 2014-08-08 14:31:54 (UTC+8)
    出版者: Pergamon Press
    摘要: A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
    關聯: Tetrahedron 70(9), pp.1800–1804
    DOI: 10.1016/j.tet.2014.01.016
    显示于类别:[化學學系暨研究所] 期刊論文

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