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    Title: Synthesis of 3-Substituted Indole by AlCl3-Promoted Reaction of α,β-unsaturated Ketone with Indole
    Authors: Lee, Shih-Yuan;Wu, Yu-Chi;Chang, Yu-Ting;Wang, Bo-Cheng
    Contributors: 淡江大學化學學系
    Keywords: Friedel–Crafts reaction Michael reaction;3-Substituted indole;β,γ-Unsaturated ketone;α,β-Unsaturated ketone
    Date: 2014-06
    Issue Date: 2014-07-11 12:13:45 (UTC+8)
    Publisher: Netherlands: Springer
    Abstract: A one-pot Lewis acid-A one-pot Lewis acid-promoted reaction condition of β,γ-unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields. A Lewis acid such as AlCl3 was shown to be a promising promoter for in situ isomerization of β,γ-unsaturated ketone to its corresponding α,β-unsaturated ketone, then undergoing Friedel–Crafts Michael addition reaction with indole to afford 3-substituted indole.
    Relation: Research on Chemical Intermediates 40(6), pp.2277-2285
    DOI: 10.1007/s11164-014-1605-x
    Appears in Collections:[化學學系暨研究所] 期刊論文

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