Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis

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Title:	Time-course gene expression profiling of high glucose-induced endothelial cell apoptosis
Authors:	Weng, Julia T.Y.;Chen, Yi-Cheng;Ma, Chung-Hsien;Lai, Tzung-Shian;Ho, Feng-Ming
Contributors:	淡江大學資訊工程學系
Keywords:	high glucose;gene expression;diabetes;timecourse analysis
Date:	2014-04
Issue Date:	2014-05-28 16:39:08 (UTC+8)
Abstract:	Diabetes is a debilitating metabolic disorder resulting from hyperglycemia and glucose intolerance. High glucose-induced endothelial dysfunction is an important contributor to vascular disease in diabetes. In this study, we profiled the global gene expression changes in human umbilical vein endothelial cells treated with high glucose at the 0-, 24-, and 48-hour intervals. Differentially expressed genes were examined through bioinformatics analysis for potential mechanisms of regulation. Our analysis uncovered novel regulatory interactions that may provide insights into the molecular transition from normal cellular activities to apoptosis under high glucose, enhancing our understanding of the mechanisms underlying vascular complications in diabetic patients.
Relation:	The 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2014), 4p.
Appears in Collections:	[Graduate Institute & Department of Computer Science and Information Engineering] Proceeding

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