淡江大學機構典藏:Item 987654321/97767
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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/97767


    Title: Low-potential amperometric determination of purine derivatives through surface oxide regeneration method
    Authors: Chen, Chi-Hao;Lin, Ya-Ting;Lin, Meng-Shan
    Contributors: 淡江大學化學學系
    Keywords: Uric acid;Xanthine;Hypoxanthine;Guanine;Adenine;Amperometry
    Date: 2013-09-24
    Issue Date: 2014-04-21 09:58:09 (UTC+8)
    Publisher: Amsterdam: Elsevier BV
    Abstract: This article described a novel amperometry which can be used for determination of purine derivatives including uric acid, xanthine, hypoxanthine, guanine, and adenine without surface contamination. By applying a constant potential of −0.125 V (vs.Ag/AgCl) in a flow injection system, the chelating capability of these purine derivatives converts the cuprous oxide layer into a soluble complex. This behavior would dissolve the passive oxide layer and expose the bottom copper layer to the solution, subsequently; an oxidation current which attributed to the regeneration of the original cuprous oxide layer is used to reflect the concentration of these purine derivatives. In a 50 mM phosphate buffer, pH 7.0, this approach provides a high sensitivity with LOQ of sub-micro molar level of five purines and high stability with a RSD of 2.5% for 10 μM xanthine (N = 12). This method does not suffer from most biological species including ascorbic acid, acetaminophen, creatine, dopamine, sarcosine, ammonium ion, chloride ion, and urea at equal or higher than its physiological concentration.
    Relation: Analytica Chimica Acta 796, pp.42–47
    DOI: 10.1016/j.aca.2013.08.011
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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