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    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/97767

    題名: Low-potential amperometric determination of purine derivatives through surface oxide regeneration method
    作者: Chen, Chi-Hao;Lin, Ya-Ting;Lin, Meng-Shan
    貢獻者: 淡江大學化學學系
    關鍵詞: Uric acid;Xanthine;Hypoxanthine;Guanine;Adenine;Amperometry
    日期: 2013-09-24
    上傳時間: 2014-04-21 09:58:09 (UTC+8)
    出版者: Amsterdam: Elsevier BV
    摘要: This article described a novel amperometry which can be used for determination of purine derivatives including uric acid, xanthine, hypoxanthine, guanine, and adenine without surface contamination. By applying a constant potential of −0.125 V (vs.Ag/AgCl) in a flow injection system, the chelating capability of these purine derivatives converts the cuprous oxide layer into a soluble complex. This behavior would dissolve the passive oxide layer and expose the bottom copper layer to the solution, subsequently; an oxidation current which attributed to the regeneration of the original cuprous oxide layer is used to reflect the concentration of these purine derivatives. In a 50 mM phosphate buffer, pH 7.0, this approach provides a high sensitivity with LOQ of sub-micro molar level of five purines and high stability with a RSD of 2.5% for 10 μM xanthine (N = 12). This method does not suffer from most biological species including ascorbic acid, acetaminophen, creatine, dopamine, sarcosine, ammonium ion, chloride ion, and urea at equal or higher than its physiological concentration.
    關聯: Analytica Chimica Acta 796, pp.42–47
    DOI: 10.1016/j.aca.2013.08.011
    顯示於類別:[化學學系暨研究所] 期刊論文


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