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| 題名: | Low-potential amperometric determination of purine derivatives through surface oxide regeneration method |
| 作者: | Chen, Chi-Hao;Lin, Ya-Ting;Lin, Meng-Shan |
| 貢獻者: | 淡江大學化學學系 |
| 關鍵詞: | Uric acid;Xanthine;Hypoxanthine;Guanine;Adenine;Amperometry |
| 日期: | 2013-09-24 |
| 上傳時間: | 2014-04-21 09:58:09 (UTC+8) |
| 出版者: | Amsterdam: Elsevier BV |
| 摘要: | This article described a novel amperometry which can be used for determination of purine derivatives including uric acid, xanthine, hypoxanthine, guanine, and adenine without surface contamination. By applying a constant potential of −0.125 V (vs.Ag/AgCl) in a flow injection system, the chelating capability of these purine derivatives converts the cuprous oxide layer into a soluble complex. This behavior would dissolve the passive oxide layer and expose the bottom copper layer to the solution, subsequently; an oxidation current which attributed to the regeneration of the original cuprous oxide layer is used to reflect the concentration of these purine derivatives. In a 50 mM phosphate buffer, pH 7.0, this approach provides a high sensitivity with LOQ of sub-micro molar level of five purines and high stability with a RSD of 2.5% for 10 μM xanthine (N = 12). This method does not suffer from most biological species including ascorbic acid, acetaminophen, creatine, dopamine, sarcosine, ammonium ion, chloride ion, and urea at equal or higher than its physiological concentration. |
| 關聯: | Analytica Chimica Acta 796, pp.42–47 |
| DOI: | 10.1016/j.aca.2013.08.011 |
| 顯示於類別: | [化學學系暨研究所] 期刊論文
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