English  |  正體中文  |  简体中文  |  Items with full text/Total items : 62572/95237 (66%)
Visitors : 2549317      Online Users : 347
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/97765

    Title: Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients
    Authors: Su, W.P.;Wen, C.C.;Hsiung, C.A.;Su, I.J.;Cheng, A.L.;Chang, M.C.;Tsao, C.J.;Kao, W.Y.;Uen, W.C.;Hsu, C.;Hsu, C.H.;Lu, Y.S.;Tien, H.F;Chao, T.Y.;Chen L.T.;Jacqueline Whang-Peng;Chen, P.J.
    Contributors: 淡江大學數學學系暨研究所
    Keywords: HBV reactivation;Liver function;Non-Hodgkin’s lymphoma;Chemotherapy
    Date: 2005-09
    Issue Date: 2014-04-21 09:05:33 (UTC+8)
    Publisher: Beijing: Beijing Baishideng BioMed Scientific Co., Ltd
    Abstract: AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma.
    METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy. Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies.
    RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years). There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P = 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P = 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis.
    CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function.
    Relation: World Journal of Gastroenterology 11(34), pp.5283-5288
    DOI: 10.3748/wjg.v11.i34.5283
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

    Files in This Item:

    File Description SizeFormat
    Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients.pdf135KbAdobe PDF1View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback