English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 58788/92495 (64%)
造访人次 : 633463      在线人数 : 37
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/97765


    题名: Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients
    作者: Su, W.P.;Wen, C.C.;Hsiung, C.A.;Su, I.J.;Cheng, A.L.;Chang, M.C.;Tsao, C.J.;Kao, W.Y.;Uen, W.C.;Hsu, C.;Hsu, C.H.;Lu, Y.S.;Tien, H.F;Chao, T.Y.;Chen L.T.;Jacqueline Whang-Peng;Chen, P.J.
    贡献者: 淡江大學數學學系暨研究所
    关键词: HBV reactivation;Liver function;Non-Hodgkin’s lymphoma;Chemotherapy
    日期: 2005-09
    上传时间: 2014-04-21 09:05:33 (UTC+8)
    出版者: Beijing: Beijing Baishideng BioMed Scientific Co., Ltd
    摘要: AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma.
    METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy. Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies.
    RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years). There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P = 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P = 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis.
    CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function.
    關聯: World Journal of Gastroenterology 11(34), pp.5283-5288
    DOI: 10.3748/wjg.v11.i34.5283
    显示于类别:[數學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML160检视/开启
    index.html0KbHTML65检视/开启
    Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients.pdf135KbAdobe PDF0检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈