English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 58335/91896 (63%)
造访人次 : 29702      在线人数 : 103
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/97756


    题名: Caffeine treatment disturbs the angiogenesis of zebrafish embryos
    作者: Yeh, C.H.;Liao, Y.F.;Chang, C.Y.;Tsai, J.N.;Wang, Y.H.;Cheng, C.C.;Wen, C.C.;Chen, Y.H.
    贡献者: 淡江大學數學學系暨研究所
    关键词: Angiogenesis;caffeine;fluorescent protein;transgenic fish;zebrafish
    日期: 2012-10
    上传时间: 2014-04-21
    出版者: New York: Informa Healthcare
    摘要: Caffeine is a widely consumed substance that occurs in numerous dietary sources, but teratogenic effects of caffeine intake during embryonic development are still not clear. In the present study, we used the zebrafish as a model to assess caffeine-induced toxicity on embryonic vascular development. A green fluorescent vascular endothelium transgenic line, Tg(fli1:egfp), was utilized for the sensitive detection of vascular development, including vasculo- and angiogenesis. Caffeine-treated embryos showed no defects in vasculogenesis, but revealed dose-dependent (250-350 ppm) developmental defects in intersegmental vessels, dorsal longitudinal anastomotic vessels, and subintestinal vein sprouting. Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c. In conclusion, caffeine treatment induces defects of angiogenesis in zebrafish embryos.
    關聯: Drug and Chemical Toxicology 35(4), pp.361-5
    DOI: 10.3109/01480545.2011.627864
    显示于类别:[數學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML139检视/开启
    index.html0KbHTML125检视/开启
    index.html0KbHTML67检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈