Flavone is efficient to protect zebrafish fins from UV-induced damage

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/97752

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题名:	Flavone is efficient to protect zebrafish fins from UV-induced damage
作者:	Tsai, I.T.;Yang, Z.S.;Lin, Z.Y.;Wen, C.C.;Cheng, C.C.;Chen, Y.H.
贡献者:	淡江大學數學學系暨研究所
关键词:	Chalcone;fin;flavone;UV;xebrafish
日期:	2012-01-31
上传时间:	2014-04-21
出版者:	New York: Informa Healthcare
摘要:	We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
關聯:	Drug and Chemical Toxicology 35(3), p.341-346
DOI:	10.3109/01480545.2011.622771
显示于类别:	[數學學系暨研究所] 期刊論文

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