English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 63246/95943 (66%)
造訪人次 : 4817812      線上人數 : 179
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/97752

    題名: Flavone is efficient to protect zebrafish fins from UV-induced damage
    作者: Tsai, I.T.;Yang, Z.S.;Lin, Z.Y.;Wen, C.C.;Cheng, C.C.;Chen, Y.H.
    貢獻者: 淡江大學數學學系暨研究所
    關鍵詞: Chalcone;fin;flavone;UV;xebrafish
    日期: 2012-01-31
    上傳時間: 2014-04-21
    出版者: New York: Informa Healthcare
    摘要: We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
    關聯: Drug and Chemical Toxicology 35(3), p.341-346
    DOI: 10.3109/01480545.2011.622771
    顯示於類別:[數學學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋