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    Title: Fin reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos
    Authors: Chen, Y.H.;Tsai, I.T.;Wen, C.C.;Wang, Y.H.;Cheng, C.C.;Hu, S.C0;Chen, Y.H.
    Contributors: 淡江大學數學學系暨研究所
    Keywords: Amikacin;fin;neuromast;ototoxicity;zebrafish
    Date: 2012-02
    Issue Date: 2014-04-21
    Publisher: New York: Informa Healthcare
    Abstract: We used zebrafish as a model to assess amikacin-induced embryotoxicity. We exposed zebrafish embryos to amikacin, using different amikacin doses (0-10 ppm), durations (12-48 h), and onsets (0, 24, 48 hpf). Amikacin-induced embryonic toxicity and reduced survival rate were found dependent on the exposure dose, duration and onset. Based on immunostaining with neuron-specific antibodies, amikacin reduced the number and size of zebrafish neuromasts. In addition, Amikacin caused pelvic, dorsal and anal fin defects in dose-dependent and duration-dependent manners. Proliferating cell nuclear antigen immunostaining revealed that amikacin-induced fin defects were not due to reduction of proliferating mesenchymal cells. TUNEL assay demonstrated that amikacin-induced fin defects might not associate with apoptosis. Therefore, further investigations are required to elucidate if other cell death pathways are involved in amikacin-induced fin defects.
    Relation: Toxicology Mechanisms and Methods 22(2), pp.151-158
    DOI: 10.3109/15376516.2011.610385
    Appears in Collections:[數學學系暨研究所] 期刊論文

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