The affinity of iron for diat. mols., O2, CO, N2, and NO, is central to the most important of life processes, including those of human physiol. This report will focus on dinitrosyl iron complexes (DNICs) that serve as biomimetics of products of FeS cluster degrdn. by excesses of NO. Whether there is a physiol. function such as NO storage in protein bound forms, or NO transport by low mol. wt. (RS)2Fe(NO)2 - (RS- = cysteine or glutathione) and histidine analogs has yet to be unambiguously established, extensive chem. and biol....
