A series of β-amino esters were synthesized by the reaction of N-tosyl aldimine or N-hydroxy aldimine with bromoacetate by sonochemical Reformatsky reaction. The β-N-hydroxyamino ester was obtained and the formed sensitive hydroxylamino functionality was resistant under the reaction condition. The β-lactam also was synthesized by the reaction of N-p-methoxy aldimine as reacting substrate under this sonochemical Reformatsky reaction condition.
Relation:
Journal of the Chinese Chemical Society 61(2), pp.290-294