Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model

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Title:	Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
Authors:	Lee, Ya-Ting;Fong, Tsorng-Harn;Chen, Hui-Min;Chang, Chao-Yuan;Wang, Yun-Hsin;Chern, Ching-Yuh;Chen, Yau-Hung
Contributors:	淡江大學化學學系
Keywords:	chalcone;embryogenesis;muscle;toxicity;zebrafish
Date:	2014-01
Issue Date:	2014-03-13 12:02:37 (UTC+8)
Publisher:	Basel: M D P I AG
Abstract:	The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.
Relation:	Molecules 19, pp.641-650
DOI:	10.3390/molecules19010641
Appears in Collections:	[Graduate Institue of Life Sciences] Journal Article

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