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    题名: Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
    作者: Lee, Ya-Ting;Fong, Tsorng-Harn;Chen, Hui-Min;Chang, Chao-Yuan;Wang, Yun-Hsin;Chern, Ching-Yuh;Chen, Yau-Hung
    贡献者: 淡江大學化學學系
    关键词: chalcone;embryogenesis;muscle;toxicity;zebrafish
    日期: 2014-01
    上传时间: 2014-03-13 12:02:37 (UTC+8)
    出版者: Basel: M D P I AG
    摘要: The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone
    (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.
    關聯: Molecules 19, pp.641-650
    DOI: 10.3390/molecules19010641
    显示于类别:[生命科學研究所] 期刊論文

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