本研究主要是以硝酸銨鈰為起始劑，合成出幾丁聚醣/丙烯酸接枝共聚合體。並對其共聚合體製成薄膜，用於吸附銅離子與鐵離子，藉此了解其吸附模式。另外進行細胞培養以了解共聚體是否有生物相容性。由實驗發現，幾丁聚醣比例較高的共聚合體對銅離子較具吸附能力。而丙烯酸含量較多的共聚合體則對鐵離子吸附性較佳。主因是共聚物中的聚丙烯酸羧酸基容易和鐵離子形成穩定的螯合物，進而吸附鐵離子。利用纖維母細胞培養生長48小時後發現細胞在共聚體上的生長情況並不佳，甚至比純幾丁聚醣還差。 In this research, a redox initiator, cerium ammonium nitrate (CAN), was used to synthesize the chitosan/acrylic acid graft copolymers. The copolymer film was prepared by oven drying. The adsorption of copper ion in this copolymer film was studied. In addition, the biocompatibility was evaluated from the cell culture on the copolymer membrane. As the amount of chitosan increased in the copolymer, the adsorption of copper ion increased. Yet, the adsorption amount of ferrite ion decreased. On the contrary, when the amount of poly(acrylic acid) increased in the copolymer, the capability of adsorption of ferrite ion increased. In the test of biocompatibility, it was found after 48h of fibroblast cell culture, the cell adhesion and growth was not very well and even worse than the pure chitosan.
2003幾丁質幾丁聚醣研討會與年會大會手冊論文集=Proceedings of 2003 Taiwan Chitin Chitosan Symposium & Agenda of Society Annual Meeting