本研究以掃流式無機薄膜過濾系統探討在不同溶液性質及操作參數下之蛋白質溶液過濾行為與結垢現象，以尋求提升濾速之操作方式。實驗溶液為BSA與β-cyclodextrin之混合溶液，操作參數有透膜壓差、濃度、pH值、液體速度及氣體速度等，定量薄膜結垢之阻力，並建立濾速分析模式。實驗結果顯示，BSA溶液之濾速在等電點時較其它pH值為低，這是因此時BSA極化層結垢較為緊密所致；含有β-cyclodextrin之雙溶質系統，其濾速較純BSA溶液來得低，此因β-cyclodextrin可進入薄膜孔道形成內部結垢所致。雙溶質系統中薄膜對β-cyclodextrin之阻隔率隨溶液pH值不同而有所改變，在BSA等電點時β-cyclodextrin之阻隔率大於遠離BSA等電點之阻隔率。在低液體流速下，通入氣體可有效提升濾速，因氣泡可以增進對膜面之擾動。 In this study, the inorganic membranes were employed in a cross-flow filitration system to discuss the flux and fouling behavior of protein solutions under various solution properties and operating parameters to search the manner for increasing the flux. Mixture of BSA and beta-cyclodextrin was selected as the testing solution and the operating parameters such as transmembrane pressure, solution concentration, pH value, liquid velocity and air velocity were considered to determine the membrane resistance and establish the model for flux analysis. Experimental result indicates that the flux of BSA solution at its isoelectric point is lower than that at other pH values; this is due to a denser polarization layer formed at its isoelectric point. Because of the internal fouling of beta-cyclodextrin, the flux of solution containing beta-cyclodextrin is lower than that of pure BSA solution. In binary solutions, the beta-cyclodextrin rejection by membrane varies with the change of pH value; the rejection of beta-cyclodextrin at the isoelectric point of BSA is higher than that at the condition far away from the BSA isoelectric point. Under low liquid velocity, flux can be increased efficiently by gas-sparging due to gas slugs increase the turbulence at the membrane surface.
