本研究是將幾丁聚醣溶於甲酸溶劑中，再加到N,N-二甲基甲醯胺與鄰苯二甲酸酐的溶液系統中，進行均相的化學反應修飾，利用鄰苯二甲酸酐與幾丁聚醣的胺基反應，藉此改善其有機溶劑溶解性，再利用幾丁聚醣上的氫氧基，來作進一步的化學接枝改質。針對產物作結構分析，結果顯示在高溫反應下，幾丁聚醣確實與鄰苯二甲酸酐有化學反應，且隨著酸酐量的增加而有轉化率增加的趨勢。反應後之產物可溶於如N,N-二甲基甲醯胺等有機溶劑。 In this study, chitosan was dissolved in formic acid and modified with phthalic anhydride in N,N-dimethylformamide(DMF) solution, through the reaction of amino group with anhydride group. In this way, chitosan can be dissolved in organic solvent. After reaction, the available hydroxyl group in the chitosan can be further used for grafting synthetic polymers onto chitosan chains. The result showed that the degree of substitution increased with the added amount of phthalic anhydride. In addition, the modified chitosan could be dissolved in several organic solvents, for example, N,N-dimethylformamide.
