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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/94364

    Title: 透析過濾操作中玻尿酸溶液之濾速行為及其純化
    Other Titles: Flux behavior and purification of hyaluronic acid solution by using diafiltration
    Authors: 王莉茹;Wang, Li-Lu
    Contributors: 淡江大學化學工程與材料工程學系碩士班
    鄭東文;Cheng, Tung-Wen
    Keywords: 透析過濾;玻尿酸;純化;電解質;Diafiltration;Hyaluronic acid;Purification;Electrolyte
    Date: 2013
    Issue Date: 2014-01-23 14:28:13 (UTC+8)
    Abstract: 本實驗採用一透析過濾裝置進行實驗,以單成分HA溶液、單成分LY溶液以及HA/LY雙成分溶液為實驗對象,並採用批次恆壓型式,針對攪拌速度、電解質種類、電解質濃度、透析液體積、透析液電解質濃度等操作變數之改變進行實驗分析。
    In this study, the HA solution, LY solution and the mixture solution of HA/LY were used as the feed solution, and experimented by adopting diafiltration in a dead-end stirred cell. The experimented results were discussed under different operating conditions such as stirred rate, electrolyte type, electrolyte concentration and diavolumes.
    The results shows that the addition of stirring can reduce the filtration resistance and improve the permeate flux. The permeate flux decreases with the increase of ion strength of electrolyte which causes the HA molecules become more shrunken and then form a compact deposited layer on membrane surface. However, the LY molecules can pass through the membrane more easily as the electrolyte is added. The strength of electrode ion will hinder the surface charge of LY, and decrease the electrostatic interference between LY molecules and membrane. During the diafiltration process of HA/LY solution, the diavolumes and electrolyte concentration can increase the removal of LY. But there is a limit to the increase of electrolyte concentration in dialyate solution, instead, would decrease the removal of LY.
    Appears in Collections:[化學工程與材料工程學系暨研究所] 學位論文

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