一新穎5,7-Dihydroxy-3',4'-Diaminoflavone抑制HER2表現並抑制HER2過表現人類卵巢癌細胞的轉移能力

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 學位論文 > Item 987654321/93996

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题名:	一新穎5,7-Dihydroxy-3',4'-Diaminoflavone抑制HER2表現並抑制HER2過表現人類卵巢癌細胞的轉移能力
其它题名:	Novel 5,7-Dihydroxy-3',4'-Diaminoflavone downregulates HER2 expression and represses metastasis-associated properties in HER2-overexpressing ovarian cancer cells
作者:	鄭欣怡;Cheng, Hsin-Yi
贡献者:	淡江大學化學學系碩士班莊子超
关键词:	人類表皮生長因子受體2;HER2
日期:	2013
上传时间:	2014-01-23 13:46:20 (UTC+8)
摘要:	類黃酮已經被研究出許多抗癌活性，包括抗增生、促進細胞凋亡、抗血管新生和細胞週期阻斷。約有30%的乳癌和卵巢癌病人有HER2基因放大或是HER2過表現的現象，且HER2過表現和細胞轉移及抗藥性有關。一系列新穎的黃酮類化合物被用來探討其對癌細胞的抗癌作用。我們發現了Cpd3 (5,7-Dihydroxy-3’,4’-Diaminoflavone)在HER2過表現癌細胞中有明顯的抗癌活性，包括抗增生、抗轉移以及促進細胞凋亡。此外，Cpd3可以增加HER2過表現細胞細胞中的HER2降解。這些結果表明，Cpd3可能是透過降低HER2的表現量以抑制HER2過表現細胞的細胞生長。 Flavonoids have been studied for their anti-tumor properties, including anti-proliferative, proapoptotic, anti-angiogenic and cell cycle arrest activities in several cancer cells. Her2 is amplified and/or overexpressed in about 30% of ovarian and breast cancers and is associated with metastasis and drug resistance. A series of novel flavones were used to explore their anticancer effects on cancer cells. We found a 5,7-Dihydroxy-3’,4’-Diaminoflavone, Cpd3, with significant anti-tumor activities in HER2-overexpressing cancer cells, including anti-proliferative, anti-metastatic, and proapoptotic activities. Moreover, Cpd3 could increase the HER2 degradation in HER2-overexpressing cells. These data suggest that cpd3 suppress the HER2-overexpressing cancer cells growth may via down-regulation of HER2.
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