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    Title: 銅金屬催化進行骨牌反應合成菲啶酮支架
    Other Titles: Copper-catalyzed domino reaction to synthesize phenanthridinone scaffold
    Authors: 吳宜聲;Wu, Yi-Sheng
    Contributors: 淡江大學化學學系碩士班
    謝仁傑;Hsieh, Jen-Chieh
    Keywords: 烏爾曼反應;骨牌反應;菲啶酮;Ullmann Reaction;Domino Reaction;ligand-free;phenanthridinones
    Date: 2013
    Issue Date: 2014-01-23 13:45:58 (UTC+8)
    Abstract: 第一部分:
    使用 Cu2O/1H-imidazole-4-carboxylic acid 高效率催化O-arylation的系統,在這系統下,僅需低耗量的Cu2O 作為催化劑,溫和的反應條件下就能夠接上廣泛類型的取代基在碘苯和酚上進行偶合反應,而得到中等以上到極佳的產率。
    第二部份:
    利用銅金屬催化進行骨牌反應並且在不使用配位基的溫合條件下用2''-溴-2-氰基聯苯(2''-bromo-2-cyanobiphenyl)進行碳-氮鍵偶合得到菲啶酮骨架化合物。這個反應可以容忍多種不同的取代基並且能得到多種具重要生物活性的菲啶酮衍生物。
    The 1st Part:
    An efficient Cu-catalyzed O-arylation was carried out by involving phenols with iodoarenes to afford various substituted diarylether derivatives with a small amount of Cu2O and 1H-imidazole-4-carboxylic acid as catalytic system under mild conditions, which provided good to excellent yields with good tolerance of functional groups.
    The 2st Part:
    Copper-catalyzed domino reaction of 2''-bromo-2-cyanobiphenyl through C-N bond formation under ligand-free and milder conditions to synthsize phenanthridinone scaffold. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives.
    Appears in Collections:[化學學系暨研究所] 學位論文

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