利用鈀金屬催化腈基引導碳 : 氫鍵活化反應合成芴酮化合物

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題名:	利用鈀金屬催化腈基引導碳 : 氫鍵活化反應合成芴酮化合物
其他題名:	Pd-catalyzed synthesis of fluorenones via nitrile directed C-H bond activation
作者:	萬勇志;Wan, Yung-Chih
貢獻者:	淡江大學化學學系碩士班謝仁傑;Hsieh, Jen-Chieh
關鍵詞:	鈀金屬催化;碳氫鍵活化;芴酮;Pd catalysis;C-H bond activation;Fluorenone
日期:	2013
上傳時間:	2014-01-23 13:45:50 (UTC+8)
摘要:	我們成功利用鈀金屬/銀離子/三氟醋酸之混合系統，催化一系列2-腈基聯苯化合物進行碳氫鍵活化與腈基插入之級聯反應，同時，使用苯甲腈與碘苯做為起始物時，透過改變銀離子來源種類與其添加量，並延長反應時間，亦可成功得到欲求產物，利用此混合系統，可建構出具有廣泛取代基容忍度與良好產率的芴酮化合物。於第三部分中，我們以2’-溴-[1,1’-聯苯]-2-甲腈做為起始物，使用格林納試劑與銅金屬催化下，成功地一步合成出菲啶化合物，而目前對於不同取代基容忍度的部分仍在進行中。 We are successfully in developing a composite system of [Pd]/[Ag]/TFA to catalyze cascade reactions of nitrile directed remote C–H bond activation with insertion of nitrile (part 1), meanwhile, as we change the starting materials from Biphenyl-2-carbonitriles to Benzonitriles and Iodobenzenes (part 2) , the desired products could also be obtained by changing the species of the silver ions donor and it’s stoichiometric amount, through the using of this composite system, variously poly-substituted fluorenones were afforded in moderate to good yields with tolerance of a wide variety of substrates. In third part, 2''-Bromo-[1,1''-biphenyl]-2-carbonitriles were as starting materials which were reacted with Grignard reagent and catalyzed by copper to synthesize phenanthridines in one-pot, further studies to explore the tolerance of the different substrates are currently underway.
顯示於類別:	[化學學系暨研究所] 學位論文

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