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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/93970

    Title: 一氫-二(取代)-吡咯之合成方法
    Other Titles: Synthesis of 1H-2-(subtutited)-pyrroles
    Authors: 馬李思慧;Ma Lee, Szu-Hui
    Contributors: 淡江大學化學學系碩士班
    李世元;Lee, Shih-Yuan
    Keywords: 加碳炔丙氨;吡咯;Homopropargylamine;Pyrrole
    Date: 2013
    Issue Date: 2014-01-23 13:44:46 (UTC+8)
    Abstract: 在許多藥物及天然物中吡咯化合物的含氮五元雜環化學結構是很重要的部分,它擁有廣泛的生物活性,例如:抗發炎、抗腫瘤及抗菌…等生物活性。另一方面,吡咯的五員雜環的物理性質也逐漸被開發重視且應用在材料方面。所以研發便捷、快速、高產率的合成方法,是本篇論文的著重的地方與努力的方向。
    Nitrogen-containing five-membered heterocycles are one of the most common subunit in many naturally occurring compounds, especically pyrrole which displays diversely and potentially biological activities.
    Pyrroles display widely biological activities such as anti-inflammatory, antibacterial, antitumor and antifungal and its functionality is gradually being developed and emphasized in material aspects of their physical and chemical properties. Therefore, we developed a novel convenient and efficient synthetic method of pyrrole which was produced under sonochemical Barbier-type reaction conditions. A reaction mixture of activated zinc (1,2 – diiodoethane as activator), propargyl bromide and imine was reacted to generate homopropagylamine, The homopropagyl- amines undergo silver(I) –catalyzed intramolecular cyclization to form dihydropyrrole. Further aromatization reactions of dihydropyrrole can afford 2-substituted pyrrole.
    Appears in Collections:[化學學系暨研究所] 學位論文

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