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    题名: Protein Crystallization Prediction with AdaBoost
    作者: Hsieh, Cheng-Wei;Hsu, Hui-Huang;Pai, Tun-Wen
    贡献者: 淡江大學資訊工程學系
    关键词: X-ray crystallography;protein crystallization;feature selection;SVM: support vector machines;AdaBoost;data mining;bioinformatics
    日期: 2013-03
    上传时间: 2014-01-09 15:03:20 (UTC+8)
    出版者: Olney: Inderscience Publishers
    摘要: To determine the structure of a protein by X-ray crystallography, the protein needs to be purified and crystallized first. However, some proteins cannot be crystallized. This makes the average cost of protein structure determination much higher. Thus it is desired to predict the crystallizability of a protein by a computational method before starting the wet-lab procedure. Features from the primary structure of a target protein are collected first. With a proper set of features, protein crystallizability can be predicted with a high accuracy. In this research, 74 features from previous researches are re-examined by two filter-mode feature selection methods. The selected features are then used for crystallization prediction by three versions of AdaBoost. The Support Vector Machines (SVMs) are also tested for comparison. The best prediction accuracy of AdaBoost reaches 93 percent and 48 important features are identified from the collected 74 features.
    關聯: International Journal of Data Mining and Bioinformatics 7(2), pp.214-227
    DOI: 10.1504/IJDMB.2013.053197
    显示于类别:[資訊工程學系暨研究所] 期刊論文

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