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    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/93290

    題名: Preparation of pH- and thermo-sensitive chitosan-PNIPAAm core–shell nanoparticles and evaluation as drug carriers
    作者: Huang, Chih-Hao;Wang, Cheng-Fan;Don, Trong-Ming;Chiu, Wen-Yen
    貢獻者: 淡江大學化學工程與材料工程學系
    關鍵詞: Chitosan;N-Isopropyl acrylamide;Self-assembly;Micelles;Drug release
    日期: 2013-08-01
    上傳時間: 2013-12-16 09:53:39 (UTC+8)
    出版者: Springer Netherlands
    摘要: Environmentally sensitive polysaccharide nanoparticles (NPs) were prepared by in situ polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) micelles. First, CS was found to develop a cationic micelle-like structure in the acetic acid solution when its concentration was increased to above the critical micelle concentration, as evidenced by fluorescence and TEM. When the NIPAAm was polymerized in the CS micelle solution by using potassium persulfate as initiator, the produced PNIPAAm with anionic chain end(s) became hydrophobic, as long as the reaction temperature was above its phase transition temperature; and therefore it would diffuse into the hydrophobic core of the CS micelles, producing CS-PNIPAAm core–shell NPs. Increasing the feeding amount of NIPAAm increased the monomer conversion and therefore the particle size; yet it decreased the surface zeta potential. Moreover, the CS-PNIPAAm NPs were sensitive to both pH value and temperature. For the study of drug release properties, doxycycline hyclate was used as a model drug and loaded into the NPs at pH 4.5 and 25 °C. The result illustrated that these NPs had a continuous drug release behavior up to 1 week, depending on the pH value and temperature. In addition, enzyme or hydrogen peroxide capable of degrading CS shell was added in the solution to facilitate the drug release.
    關聯: Cellulose 20(4), pp.1791–1805
    DOI: 10.1007/s10570-013-9951-1
    顯示於類別:[化學工程與材料工程學系暨研究所] 期刊論文


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