English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 62572/95237 (66%)
造訪人次 : 2547931      線上人數 : 283
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/93107

    題名: Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy
    作者: Chen, Hong-Wen;Hsu, Fei-Ting;Chang, Yue-Cune;Tu, Hsi-Feng;Fang, Chun-Kai;Kuo, Shu-Ping;Hwang, Jeng-Jong
    貢獻者: 淡江大學數學學系
    關鍵詞: HPRT;oral cancer;radiotherapy;variant frequency
    日期: 2013-06-01
    上傳時間: 2013-11-21 14:47:15 (UTC+8)
    出版者: 臺北市:臺灣調適科學會
    摘要: Effect of ionizing radiation on the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) gene in the peripheral lymphocytes of patients with oral cancer was studied. Subjects were randomly separated into five groups: A) healthy subjects without smoking and betel quid chewing habits; B) are healthy non-smokers but with betel quid chewing habit. Patients with oral cancer are all smokers and betel quid users, and are separated into three groups: pre-, during, and six months after radiotherapy (RT), respectively. The HPRT variant frequencies (Vfs) of groups A and B are (8.68 ± 2.1) × 10^(-6) and (9.48 ± 3.73) × 10^(-6), respectively. Notably, Vfs are (10.02 ± 2.68) × 10^(-6), (92.75 ± 17.48) × 10^(-6) and (61.72 ± 16.65) × 10^(-6), respectively, for groups C, D, and E. Both during- and post-RT groups demonstrate a significantly higher HPRT Vf as compared with that of pre-RT (P < 0.01). The effect of gender on HPRT Vf was also found in post-RT group (P < 0.05). In conclusion, oral cancer patients treated with RT resulted in the increase of HPRT gene mutation during and even six months post the treatment.
    關聯: 調適醫學=Adaptive Medicine 5(2),頁83-91
    DOI: 10.4247/AM.2013.ABD054
    顯示於類別:[數學學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數
    Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy.pdf2552KbAdobe PDF2檢視/開啟



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋