Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy

doi:10.4247/AM.2013.ABD054

淡江大學機構典藏 > 理學院 > 數學學系暨研究所 > 期刊論文 > Item 987654321/93107

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Title:	Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy
Authors:	Chen, Hong-Wen;Hsu, Fei-Ting;Chang, Yue-Cune;Tu, Hsi-Feng;Fang, Chun-Kai;Kuo, Shu-Ping;Hwang, Jeng-Jong
Contributors:	淡江大學數學學系
Keywords:	HPRT;oral cancer;radiotherapy;variant frequency
Date:	2013-06-01
Issue Date:	2013-11-21 14:47:15 (UTC+8)
Publisher:	臺北市：臺灣調適科學會
Abstract:	Effect of ionizing radiation on the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) gene in the peripheral lymphocytes of patients with oral cancer was studied. Subjects were randomly separated into five groups: A) healthy subjects without smoking and betel quid chewing habits; B) are healthy non-smokers but with betel quid chewing habit. Patients with oral cancer are all smokers and betel quid users, and are separated into three groups: pre-, during, and six months after radiotherapy (RT), respectively. The HPRT variant frequencies (Vfs) of groups A and B are (8.68 ± 2.1) × 10^(-6) and (9.48 ± 3.73) × 10^(-6), respectively. Notably, Vfs are (10.02 ± 2.68) × 10^(-6), (92.75 ± 17.48) × 10^(-6) and (61.72 ± 16.65) × 10^(-6), respectively, for groups C, D, and E. Both during- and post-RT groups demonstrate a significantly higher HPRT Vf as compared with that of pre-RT (P < 0.01). The effect of gender on HPRT Vf was also found in post-RT group (P < 0.05). In conclusion, oral cancer patients treated with RT resulted in the increase of HPRT gene mutation during and even six months post the treatment.
Relation:	調適醫學=Adaptive Medicine 5(2)，頁83-91
DOI:	10.4247/AM.2013.ABD054
Appears in Collections:	[數學學系暨研究所] 期刊論文

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