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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/93107

    Title: Hypoxanthine-Guanine Phosphoribosyl-Transferase Gene Mutation in Oral Cancer Patients Treated with Radiotherapy
    Authors: Chen, Hong-Wen;Hsu, Fei-Ting;Chang, Yue-Cune;Tu, Hsi-Feng;Fang, Chun-Kai;Kuo, Shu-Ping;Hwang, Jeng-Jong
    Contributors: 淡江大學數學學系
    Keywords: HPRT;oral cancer;radiotherapy;variant frequency
    Date: 2013-06-01
    Issue Date: 2013-11-21 14:47:15 (UTC+8)
    Publisher: 臺北市:臺灣調適科學會
    Abstract: Effect of ionizing radiation on the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) gene in the peripheral lymphocytes of patients with oral cancer was studied. Subjects were randomly separated into five groups: A) healthy subjects without smoking and betel quid chewing habits; B) are healthy non-smokers but with betel quid chewing habit. Patients with oral cancer are all smokers and betel quid users, and are separated into three groups: pre-, during, and six months after radiotherapy (RT), respectively. The HPRT variant frequencies (Vfs) of groups A and B are (8.68 ± 2.1) × 10^(-6) and (9.48 ± 3.73) × 10^(-6), respectively. Notably, Vfs are (10.02 ± 2.68) × 10^(-6), (92.75 ± 17.48) × 10^(-6) and (61.72 ± 16.65) × 10^(-6), respectively, for groups C, D, and E. Both during- and post-RT groups demonstrate a significantly higher HPRT Vf as compared with that of pre-RT (P < 0.01). The effect of gender on HPRT Vf was also found in post-RT group (P < 0.05). In conclusion, oral cancer patients treated with RT resulted in the increase of HPRT gene mutation during and even six months post the treatment.
    Relation: 調適醫學=Adaptive Medicine 5(2),頁83-91
    DOI: 10.4247/AM.2013.ABD054
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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