Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation

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Title:	Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation
Authors:	Chai, Chih-Cheng;Liu, Pin-Yi;Lin, Chia-Hung;Chen, Hsien-Chi;Wu, Yang-Chang;Chang, Fang-Rong;Pan, Po-Shen
Contributors:	淡江大學化學學系
Keywords:	boron;multicomponent reaction;Passerini reaction;HepG2
Date:	2013-08-08
Issue Date:	2013-10-22 16:44:34 (UTC+8)
Publisher:	M D P I AG
Abstract:	In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
Relation:	Molecules 18(8), pp.9488-9511
DOI:	10.3390/molecules18089488
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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