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    题名: Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation
    作者: Chai, Chih-Cheng;Liu, Pin-Yi;Lin, Chia-Hung;Chen, Hsien-Chi;Wu, Yang-Chang;Chang, Fang-Rong;Pan, Po-Shen
    贡献者: 淡江大學化學學系
    关键词: boron;multicomponent reaction;Passerini reaction;HepG2
    日期: 2013-08-08
    上传时间: 2013-10-22 16:44:34 (UTC+8)
    出版者: M D P I AG
    摘要: In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
    關聯: Molecules 18(8), pp.9488-9511
    DOI: 10.3390/molecules18089488
    显示于类别:[化學學系暨研究所] 期刊論文

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