English  |  正體中文  |  简体中文  |  Items with full text/Total items : 57310/90913 (63%)
Visitors : 13001756      Online Users : 246
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/92789

    Title: Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation
    Authors: Chai, Chih-Cheng;Liu, Pin-Yi;Lin, Chia-Hung;Chen, Hsien-Chi;Wu, Yang-Chang;Chang, Fang-Rong;Pan, Po-Shen
    Contributors: 淡江大學化學學系
    Keywords: boron;multicomponent reaction;Passerini reaction;HepG2
    Date: 2013-08-08
    Issue Date: 2013-10-22 16:44:34 (UTC+8)
    Publisher: M D P I AG
    Abstract: In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
    Relation: Molecules 18(8), pp.9488-9511
    DOI: 10.3390/molecules18089488
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

    Files in This Item:

    File Description SizeFormat
    molecules-18-09488.pdf論文主文600KbAdobe PDF194View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback