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    題名: The risk for bacterial endocarditis in cirrhotic patients: a population-based 3-year follow-up study
    作者: Hung, Tsung-Hsing;Hsieh, Yu-Hsi;Tseng, Kuo-Chih;Tsai, Chih-Chun;Tsai, Chen-Chi
    貢獻者: 淡江大學數學學系
    關鍵詞: Cirrhosis;Bacterial endocarditis;Risk factor
    日期: 2013-06
    上傳時間: 2013-10-08 10:54:24 (UTC+8)
    出版者: London: Elsevier Ltd
    摘要: Background
    We noted only rare reports of cirrhotic patients with bacterial endocarditis (BE). There is insufficient data on the risk of BE in liver cirrhosis. This is the first national population-based study evaluating the risk of BE in cirrhotic patients.
    Methods
    We used the National Health Insurance Database, which is derived from the Taiwan National Health Insurance Program. The study cohort comprised 40 803 patients with cirrhosis and the comparison cohort consisted of 40 841 randomly selected subjects with a similar age and sex distribution.
    Results
    Of the total 81 644 patients, 192 (0.24%) experienced BE during the 3-year follow-up period, 121 patients from the study cohort (0.30% of the cirrhotic patients) and 71 patients from the comparison group (0.17% of non-cirrhotic patients) (p<0.001). After adjusting for patient age, sex, and comorbid disorders, the Cox regression analysis showed that cirrhotic patients had a high risk of BE compared to non-cirrhotic patients during the 3-year follow-up period (hazard ratio 2.04, 95% confidence interval 1.61–2.44, p<0.001).
    Conclusion
    We conclude that liver cirrhosis is a risk factor for the occurrence of BE.
    關聯: International Journal of Infectious Diseases 17(6), pp.e391-e393
    DOI: 10.1016/j.ijid.2012.12.009
    顯示於類別:[數學學系暨研究所] 期刊論文

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