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    题名: Influence of Blood Vessel on the Thermal Lesion Formation during Radio Frequency Ablation for Liver Tumors
    作者: Huang, Huang-Wen
    贡献者: 淡江大學資訊創新與科技學系
    关键词: radiofrequency ablation (RFA), liver ablation, liver tumor, heat sink effect, thermally significant blood vessels, computer simulation
    日期: 2013-06-18
    上传时间: 2013-09-16 19:44:38 (UTC+8)
    出版者: College Park: American Association of Physicists in Medicine
    摘要: Purpose: The major obstacles of radiofrequency ablation (RFA) heat treatments are nonuniform heating in the thermal lesion and heat sinks caused by large blood vessels during treatments which could lead to high tumor recurrence in patients. The objective of this study is to help comprehend RFA heat treatment through thermal lesion formation using computer simulation, and thus to provide helpful assistance in planning RFA.
    Methods: RFA heat treatment is a popular “minimally invasive” treatment method for both primary and metastatic liver tumors, and the heat treatment is studied by numerical calculation. A finite difference model is used to solve all partial differential equations for a simple three-dimensional cubic geometry model. Maximum tissue temperature is used as a critical index for reaching thermal lesion during RFA. Cylindrical RF cool-tip electrode is internally cooled at constant water temperature. RFA thermal lesion is studied at various impacts by single and countercurrent blood vessel(s) traversing
    the thermal lesion. Several factors are considered, such as location, diameter, and orientation of the blood vessel(s) to the electrode.
    Results: Results show the thermal lesion size decreases as the lesion blood perfusion rate increases. And, single large blood vessel which is orthogonal to RF electrode will cause less undercooled volume in the thermal lesion than one which is parallel to RF electrode. Furthermore, convective energy may easily damage parallel vessel and its surrounding normal tissues during RFA. Small blood vessels (or larger vessels with slow blood flow rate) during RFA could form “tail-like” thermal lesion formation, which could damage vessel downstream spots.
    Conclusions: Studies suggested that incomplete RF tumor ablation still exists within 1 cm distance
    between large blood vessel and RF electrode in a liver. This could have significant impact on local
    tumor recurrence rates. Second, if thermally significant vessel existed inevitably within the lesion, avoiding the RF cool-tip electrode placement next to the parallel large blood vessel would have a better heat treatment during RF heating. Additionally, reduced blood flow rate could help reduce significant cooling by large blood vessel.
    關聯: Medical Physics 40(7), 073303(13pages)
    DOI: 10.1118/1.4811135
    显示于类别:[資訊創新與科技學系] 期刊論文

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