Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/91704

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題名:	Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
作者:	Chen, Yau-hung;Wang, Wei-Hua;Wang, Yun-Hsin;Lin, Zi-Yu;Wen, Chi-Chung;Chern, Ching-Yuh
貢獻者:	淡江大學化學學系淡江大學數學學系
關鍵詞:	anti-inflammation;chalcone;fin;zebrafish
日期:	2013-02-01
上傳時間:	2013-07-29 09:26:07 (UTC+8)
出版者:	Basel: M D P I AG
摘要:	The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
關聯:	Molecules 18(2), pp.2052-2060
DOI:	10.3390/molecules18022052
顯示於類別:	[數學學系暨研究所] 期刊論文 [化學學系暨研究所] 期刊論文

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