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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/91704

    Title: Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
    Authors: Chen, Yau-hung;Wang, Wei-Hua;Wang, Yun-Hsin;Lin, Zi-Yu;Wen, Chi-Chung;Chern, Ching-Yuh
    Contributors: 淡江大學化學學系
    Keywords: anti-inflammation;chalcone;fin;zebrafish
    Date: 2013-02-01
    Issue Date: 2013-07-29 09:26:07 (UTC+8)
    Publisher: Basel: M D P I AG
    Abstract: The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
    Relation: Molecules 18(2), pp.2052-2060
    DOI: 10.3390/molecules18022052
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article
    [Graduate Institute & Department of Chemistry] Journal Article

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