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    题名: Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
    作者: Chen, Yau-hung;Wang, Wei-Hua;Wang, Yun-Hsin;Lin, Zi-Yu;Wen, Chi-Chung;Chern, Ching-Yuh
    贡献者: 淡江大學化學學系
    关键词: anti-inflammation;chalcone;fin;zebrafish
    日期: 2013-02-01
    上传时间: 2013-07-29 09:26:07 (UTC+8)
    出版者: Basel: M D P I AG
    摘要: The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
    關聯: Molecules 18(2), pp.2052-2060
    DOI: 10.3390/molecules18022052
    显示于类别:[數學學系暨研究所] 期刊論文
    [化學學系暨研究所] 期刊論文


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