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    題名: Amikacin-induced Fin Reduction is Mediated by Autophagy
    作者: Tsai, I-Ting;Chen, Yau-Hung;Wang, Yun-Hsin
    貢獻者: 淡江大學生命科學研究所
    關鍵詞: amikacin;autophagy;embryotoxicity;fin reduction;zebrafish
    日期: 2013-03-01
    上傳時間: 2013-07-29 09:22:45 (UTC+8)
    出版者: Tokyo: Japanese Society of Toxicologic Pathology
    摘要: Despite its medical use, little is known about the mechanisms underlying amikacin-induced embryotoxicity, including fin reduction, in zebrafish. In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 (autophagy-related gene), atg12 and LC3 (mammalian homolog of Atg8) in amikacin-treated zebrafish embryos. Our results indicated that the mRNA expression level of atg12 in the amikacin-treated group was significantly increased by 1.5-fold (p<0.05) compared with the corresponding mock control group, while the expression levels of atg10 and mTOR were significantly decreased by 0.74-fold (p<0.05) and 0.58-fold (p<0.05), respectively. Western blot analysis revealed that LC3 protein expression was induced by amikacin. Taken together, these data suggest that amikacin-induced fin reduction is mediated by fin cell autophagy.
    關聯: Journal of Toxicologic Pathology 26(1), pp.79-82
    DOI: 10.1293/tox.26.79
    顯示於類別:[化學學系暨研究所] 期刊論文

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