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    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/89026

    題名: Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
    作者: Kuo, Han-Peng;Chuang, Tzu-Chao;Yeh, Ming-Han;Hsu, Shih-Chung;Way, Tzong-Der;Chen, Po-Yuan;Wang, Shan-Shue;Chang, Yung-Hsien;Kao, Ming-Ching;Liu, Jah-Yao
    貢獻者: 淡江大學化學學系
    關鍵詞: berberine;breast cancer;HER2;PI3K/Akt signaling cascade;apoptosis;cell cycle arrest
    日期: 2011
    上傳時間: 2013-05-03 16:37:41 (UTC+8)
    出版者: Washington, DC: American Chemical Society
    摘要: Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells. This study investigated the molecular mechanisms by which BBR suppresses the growth of HER2-overexpressing breast cancer cells. The results show that BBR induces G1-phase cell cycle arrest by interfering with the expression of cyclins D1 and E and that it induces cellular apoptosis through the induction of a mitochondria/caspase pathway. The data also indicate that BBR inhibits cellular growth and promotes apoptosis by down-regulating the HER2/PI3K/Akt signaling pathway. Furthermore, it is also shown that a combination of taxol and BBR significantly slows the growth rate of HER2-overexpressing breast cancer cells. In conclusion, this study suggests that BBR could be a useful adjuvant therapeutic agent in the treatment of HER2-overexpressing breast cancer.
    關聯: Journal of Agricultural and Food Chemistry 59(15), pp.8216–8224
    DOI: 10.1021/jf2012584
    顯示於類別:[化學學系暨研究所] 期刊論文


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