English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 55224/89525 (62%)
造訪人次 : 10723573      線上人數 : 32
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/89026


    題名: Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
    作者: Kuo, Han-Peng;Chuang, Tzu-Chao;Yeh, Ming-Han;Hsu, Shih-Chung;Way, Tzong-Der;Chen, Po-Yuan;Wang, Shan-Shue;Chang, Yung-Hsien;Kao, Ming-Ching;Liu, Jah-Yao
    貢獻者: 淡江大學化學學系
    關鍵詞: berberine;breast cancer;HER2;PI3K/Akt signaling cascade;apoptosis;cell cycle arrest
    日期: 2011
    上傳時間: 2013-05-03 16:37:41 (UTC+8)
    出版者: Washington, DC: American Chemical Society
    摘要: Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells. This study investigated the molecular mechanisms by which BBR suppresses the growth of HER2-overexpressing breast cancer cells. The results show that BBR induces G1-phase cell cycle arrest by interfering with the expression of cyclins D1 and E and that it induces cellular apoptosis through the induction of a mitochondria/caspase pathway. The data also indicate that BBR inhibits cellular growth and promotes apoptosis by down-regulating the HER2/PI3K/Akt signaling pathway. Furthermore, it is also shown that a combination of taxol and BBR significantly slows the growth rate of HER2-overexpressing breast cancer cells. In conclusion, this study suggests that BBR could be a useful adjuvant therapeutic agent in the treatment of HER2-overexpressing breast cancer.
    關聯: Journal of Agricultural and Food Chemistry 59(15), pp.8216–8224
    DOI: 10.1021/jf2012584
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML223檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋