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    Title: Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
    Authors: Kuo, Han-Peng;Chuang, Tzu-Chao;Yeh, Ming-Han;Hsu, Shih-Chung;Way, Tzong-Der;Chen, Po-Yuan;Wang, Shan-Shue;Chang, Yung-Hsien;Kao, Ming-Ching;Liu, Jah-Yao
    Contributors: 淡江大學化學學系
    Keywords: berberine;breast cancer;HER2;PI3K/Akt signaling cascade;apoptosis;cell cycle arrest
    Date: 2011
    Issue Date: 2013-05-03 16:37:41 (UTC+8)
    Publisher: Washington, DC: American Chemical Society
    Abstract: Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells. This study investigated the molecular mechanisms by which BBR suppresses the growth of HER2-overexpressing breast cancer cells. The results show that BBR induces G1-phase cell cycle arrest by interfering with the expression of cyclins D1 and E and that it induces cellular apoptosis through the induction of a mitochondria/caspase pathway. The data also indicate that BBR inhibits cellular growth and promotes apoptosis by down-regulating the HER2/PI3K/Akt signaling pathway. Furthermore, it is also shown that a combination of taxol and BBR significantly slows the growth rate of HER2-overexpressing breast cancer cells. In conclusion, this study suggests that BBR could be a useful adjuvant therapeutic agent in the treatment of HER2-overexpressing breast cancer.
    Relation: Journal of Agricultural and Food Chemistry 59(15), pp.8216–8224
    DOI: 10.1021/jf2012584
    Appears in Collections:[化學學系暨研究所] 期刊論文

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