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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/87429

    Title: 有機錫類化合物與疊氮化物進行"Click"反應合成三氮二烯五環化合物[2+2+2]-環化反應合成含氮多環芳香族化合物
    Other Titles: Click reaction of alkynyl stannane with aryl azide and synthesis of N-polyaromatic compounds via [2+2+2]-cycloaddition reaction
    Authors: 林育祥;Lin, Yu-Hsiang
    Contributors: 淡江大學化學學系碩士班
    李世元;Lee, Shih-Yuan
    Keywords: Click化學;[2+2+2]環化反應;Click Chemistry;[2+2+2]-Cycloaddition
    Date: 2012
    Issue Date: 2013-04-13 11:04:47 (UTC+8)
    Abstract: 部分一:

    Part I:
    [1,2,3]-Triazoles often exhibit biological activity which may be used as antibacterial or anti-HIV drug.Aryl halides were converted to a variety of aryl azide and which were further reacted with alkynyl stannane by “Click” reaction to produce triazole compounds.

    Part II:
    Nitrogen-containing polycyclic aromatic compounds generally exhibit biologically activities such as anti-cancer or anti-bacterial activities.The coupling reaction of 2-ethynylbenzaldehyde with various haloaromatic compounds or the coupling reaction of 2-bromobenzaldehyde with a variety of terminal alkynes can produce alkynyl benzaldehydes.
    The alkynyl benzaldehyde was reacted with propargyl bromide via Barbier-type reaction to generate the expected alkynyl homopropargyl alcohol.
    The alkynyl homopropargyl alcohol was reacted with phenylcyanide to afford nitrogen-containing polyaromatic compounds by [2+2+2]-cycloaddition reaction.
    Appears in Collections:[化學學系暨研究所] 學位論文

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