部分二: 含氮多環芳香族化合物的衍生物通常具有生物活性用來抗癌及抗菌等功能，我們以2-乙炔基苯甲醛與鹵素芳香族化合物進行偶合反應，或以2-溴苯甲醛與末端炔芳香族化合物進行偶合反應，再以巴比艾爾型式反應將丙炔基鹵化物對醛類進行加成反應來合成加碳炔丙基醇化合物。將加碳炔丙基醇化合物與氰化苯進行[2+2+2]-環化反應，即可合成含氮多環芳香族化合物。 Part I: [1,2,3]-Triazoles often exhibit biological activity which may be used as antibacterial or anti-HIV drug.Aryl halides were converted to a variety of aryl azide and which were further reacted with alkynyl stannane by “Click” reaction to produce triazole compounds.
Part II: Nitrogen-containing polycyclic aromatic compounds generally exhibit biologically activities such as anti-cancer or anti-bacterial activities.The coupling reaction of 2-ethynylbenzaldehyde with various haloaromatic compounds or the coupling reaction of 2-bromobenzaldehyde with a variety of terminal alkynes can produce alkynyl benzaldehydes. The alkynyl benzaldehyde was reacted with propargyl bromide via Barbier-type reaction to generate the expected alkynyl homopropargyl alcohol. The alkynyl homopropargyl alcohol was reacted with phenylcyanide to afford nitrogen-containing polyaromatic compounds by [2+2+2]-cycloaddition reaction.
