胺基環醣醇 (aminocyclitols) 類化合物為醣水解酵素抑制劑。有文獻指出，抑制醣水解酵素可有效治療癌症、糖尿病、病毒感染和一些代謝性疾病，所以合成化學家的興趣，在於進一步的設計與合成這類分子以作為醫藥用途。 胺基環醣醇類化合物，因其具備和醣類相似結構，和醣水解酵素之間有著特別的抑制作用，進一步被發展為醣水解酵素抑制劑。我們以便宜具對掌性質之D-( Aminocyclitols can mimic oligosaccharides to make them as glycosidases inhibitors. Glycosidse inhibitors posses therapeutic potential in the treatment of a variety of carbohydrate-mediated diseases and cancers. We described herein an alternative synthesis of two known aminocyclitols and two new aminocyclitols. Each synthesis was accomplished in eight steps via a regioselective ring opening reaction of epoxides. On the other hand, many bisinbolymaleimide compounds, like Arcyriaflavin A, have been reported as inhibitors of protein kinase C. This family of isoenzymes is believed to control growth and proliferation of a wide range of cancer cell. The most effecient synthesis of Arcyriaflavin A has been reported by reaction of indolymagnesium bromide with N-protected dibromomaleimide.We wish to report a more convenient method by using Diels-Alder method.
