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    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/87405

    題名: 利用D-(-)-Quinic Acid合成Aminocyclitols及合成Arcyriaflavin A作為具有潛力之抗癌藥物
    其他題名: Synthesis of Aminocyclitols from D-(-)-Quinic Acid and synthesis of Arcyriaflavin a as potential anticancer drugs
    作者: 楊淑喻;Yang, Shu-Yu
    貢獻者: 淡江大學化學學系碩士班
    施增廉;Shih, Tzenge-Lien
    關鍵詞: 胺基環醣醇;醣水解酵素抑制劑;雙吲哚亞醯胺;D-(-)-Quinic;Glycosidase inhibitor;aminocyclitols;Arcyriaflavin A;indolocarbazole alkaloid
    日期: 2012
    上傳時間: 2013-04-13 11:03:26 (UTC+8)
    摘要: 胺基環醣醇 (aminocyclitols) 類化合物為醣水解酵素抑制劑。有文獻指出,抑制醣水解酵素可有效治療癌症、糖尿病、病毒感染和一些代謝性疾病,所以合成化學家的興趣,在於進一步的設計與合成這類分子以作為醫藥用途。
    Aminocyclitols can mimic oligosaccharides to make them as glycosidases inhibitors. Glycosidse inhibitors posses therapeutic potential in the treatment of a variety of carbohydrate-mediated diseases and cancers.
    We described herein an alternative synthesis of two known aminocyclitols and two new aminocyclitols. Each synthesis was accomplished in eight steps via a regioselective ring opening reaction of epoxides.
    On the other hand, many bisinbolymaleimide compounds, like Arcyriaflavin A, have been reported as inhibitors of protein kinase C. This family of isoenzymes is believed to control growth and proliferation of a wide range of cancer cell.
    The most effecient synthesis of Arcyriaflavin A has been reported by reaction of indolymagnesium bromide with N-protected dibromomaleimide.We wish to report a more convenient method by using Diels-Alder method.
    顯示於類別:[化學學系暨研究所] 學位論文


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