Synthesis of Chitosan Copolymers Selectively Grafted withPoly(N-Isopropylacrylamide)

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Title:	Synthesis of Chitosan Copolymers Selectively Grafted withPoly(N-Isopropylacrylamide)
Other Titles:	幾丁聚醣選擇性接枝聚異丙基丙烯醯胺以合成出共聚合體水膠
Authors:	董崇民;Don, Trong-Ming;方裕榮;Fang, Yu-Jung;陳怡雯;Chen, I-Wen
Contributors:	淡江大學化學工程與材料工程學系
Keywords:	Chitosan;Poly(N-isopropylacrylamide);Glycidyl methacrylate;Graft copolymer
Date:	2006
Issue Date:	2013-04-09 11:46:48 (UTC+8)
Abstract:	In this study, poly(N-isopropylacrylamide)(PNIPAAm) was selectively grafted onto chitosan to form a copolymer hydrogel. To accomplish this goal, the amino group of chitosan (CS) was protected by reaction with phthalic anhydride, which also rendered the modified chitosan soluble in organic solvent. The N-phthaloyl chitosan was then reacted with glycidyl methacrylate (GMA) selectively through hydroxyl groups in glucopyranose rings, to provide vinyl functional groups for further graft copolymerization with NIPAAm monomer by free radical polymerization. The phthaloyl groups were removed under the reaction with hydrazine solution. Structures of the intermediates and final CS-g-PNIPAAm copolymer products were analyzed by Fourier transform infrared spectrometer and nuclear magnetic resonance. Several properties such as swelling behavior, thermal properties and cell compatibility of the formed chitosan-g-PNIPAAm copolymers were evaluated.
Relation:	2006 台灣幾丁質幾丁聚醣研討會論文集, 4p.
Appears in Collections:	[Graduate Institute & Department of Chemical and Materials Engineering] Proceeding

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