English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 61875/94645 (65%)
造訪人次 : 1635363      線上人數 : 7
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/80398

    題名: Mathematical model of heterogeneous cancer growth with an autocrine signalling pathway
    作者: Hu, G.-M.;Lee, C.-Y.;Chen, Y.-Y.;Pang, N.-N.;Tzeng, W. J.
    貢獻者: 淡江大學物理學系
    日期: 2012-10
    上傳時間: 2013-01-23 16:30:32 (UTC+8)
    出版者: Chichester: Wiley-Blackwell Publishing Ltd.
    摘要: Objectives
    Cancer is a complex biological occurrence which is difficult to describe clearly and explain its growth development. As such, novel concepts, such as of heterogeneity and signalling pathways, grow exponentially and many mathematical models accommodating the latest knowledge have been proposed. Here, we present a simple mathematical model that exhibits many characteristics of experimental data, using prostate carcinoma cell spheroids under treatment.

    Materials and methods
    We have modelled cancer as a two-subpopulation system, with one subpopulation representing a cancer stem cell state, and the other a normal cancer cell state. As a first approximation, these follow a logistical growth model with self and competing capacities, but they can transform into each other by using an autocrine signalling pathway.

    Results and conclusion
    By analysing regulation behaviour of each of the system parameters, we show that the model exhibits many characteristics of actual cancer growth curves. Features reproduced in this model include delayed phase of evolving cancer under 17AAG treatment, and bi-stable behaviour under treatment by irradiation. In addition, our interpretation of the system parameters corresponds well with known facts involving 17AAG treatment. This model may thus provide insight into some of the mechanisms behind cancer.
    關聯: Cell Proliferation 45(5), pp.445-455
    DOI: 10.1111/j.1365-2184.2012.00835.x
    顯示於類別:[物理學系暨研究所] 期刊論文


    檔案 描述 大小格式瀏覽次數
    Hu12.pdf1337KbAdobe PDF344檢視/開啟



    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋