淡江大學機構典藏:Item 987654321/80151
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 62830/95882 (66%)
造访人次 : 4035385      在线人数 : 841
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/80151


    题名: Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation.
    作者: Kuo, Han-Peng;Chuang, Tzu-Chao;Tsai, Shih-Chang;Tseng, Hsiu-Hsueh;Hsu, Shih-Chung;Chen, Yu-Chang;Kuo, Chao-Lin;Kuo, Yueh-Hsiung;Liu, Jah-Yao;Kao, Ming-Ching
    贡献者: 淡江大學化學學系
    关键词: berberine;breast cancer;Akt/PKB;matrix metalloproteinases;metastasis
    日期: 2012-09
    上传时间: 2013-01-18 15:55:19 (UTC+8)
    出版者: Washington: American Chemical Society
    摘要: Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells. In this study, we investigated the molecular mechanisms by which BBR repressed the metastatic potential of breast cancer cells. BBR was found to downregulate the enzymatic activities and expression levels of matrix metalloproteinases 2 and 9 (MMP2 and MMP9, respectively). The BBR-mediated suppression of MMP2 and MMP9 involved the inhibition of the Akt/nuclear factor kappa B (NF-κB) and activator protein-1 (AP-1) signaling pathways. Furthermore, BBR repressed the expression of the Akt protein by modulating the mRNA expression level and protein degradation of Akt. In conclusion, this study suggests that BBR can reduce the metastatic potential of highly metastatic breast cancer cells and may be a useful adjuvant therapeutic agent in the treatment of breast cancer by targeting the Akt pathway.
    關聯: Journal of Agricultural and Food Chemistry 60(38), pp.9649-9658
    DOI: 10.1021/jf302832n
    显示于类别:[化學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation.pdf2343KbAdobe PDF2检视/开启
    index.html0KbHTML286检视/开启
    index.html0KbHTML171检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈