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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/80053


    Title: Isolation and Identification of a Novel Antioxidant with Antitumour Activity from Serratia ureilytica Using Squid Pen as Fermentation Substrate
    Authors: Kuo, Yao-Haur;Liang, Tzu-Wen;Liu, Kao-Cheng;Hsu, Ya-Wen;,Hsu, Hsiu-Ching;Wang, San-Lang
    Contributors: 淡江大學化學學系
    Keywords: α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds
    Date: 2011-06
    Issue Date: 2013-01-17 09:15:34 (UTC+8)
    Publisher: New York: Springer New York LLC
    Abstract: The antioxidant activity of the culture supernatant of Serratia ureilytica TKU013 with squid pen as the sole carbon/nitrogen source was assessed by three methods, and the phenolic contents were assayed. The supernatant with the highest antioxidant activity was further purified by liquid–liquid partition, revealing the ethyl acetate extract exhibited the strongest antioxidant activity and the highest total phenolic content. Eight fractions were retrieved from silica gel column chromatography of this extract, designated F1–F8. F4 was found to possess the strong antioxidative activity and the highest total phenolic content and also exhibited strong cytotoxic activities against two different tumoural cell lines. A new compound (Serranticin) with antioxidant and antitumor activity was obtained from F4. The structure of Serranticin is analogous to that of siderophores (hexacoordinated catecholamine), which are iron chelators. As such, Serranticin has the potential for use as a deferration agent in various iron overload diseases.
    Relation: Marine Biotechnology 13(3), p.451-461
    DOI: 10.1007/s10126-010-9316-9
    Appears in Collections:[化學學系暨研究所] 期刊論文

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