A series of 2-arylbenzothiazoles was synthesized from the condensation reaction of aryl aldehyde with 2-aminothiophenol in the presence of L-proline under solvent-free and microwave irradiation conditions. Aromatic acids and aliphatic acids also gave the desired products in good to moderate yields under the reaction conditions. The product yields of using carboxylic acids with 2-aminothiophenol were generally lower than those of using aldehydes. This microwave-assisted L-proline catalyzed reaction provides a green and inexpensive preparation method for synthesis of 2-arylbenzothiazoles.
Journal of Applied Science and Engineering 15(3), pp.311-315