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    題名: A Novel Compound with Antioxidant Activity Produced by Serratia ureilytica TKU013
    作者: Kuo, Yao-Haur;Hsu, Hsiu-Ching;Chen, Yu-Chi;Liang, Tzu-Wen;Wang, San-Lang
    貢獻者: 淡江大學生命科學研究所
    關鍵詞: Serratia ureilytica;serlyticin-A;squid pen;antioxidant activity;cytotoxicity;DPPH
    日期: 2012-08-28
    上傳時間: 2013-01-08 14:20:31 (UTC+8)
    出版者: Washington, DC: American Chemical Society
    摘要: The secondary metabolites from the cultured supernatant of Serratia ureilytica TKU013 with squid pen as the sole carbon/nitrogen source were isolated and ascertained the mechanism of biological activity. The EtOAc layer, which has high DPPH scavenging activity, was applied to silica gel column chromatography with a gradient of CH2Cl2/MeOH solvent system, to yield A–H and MeOH fractions. The DPPH scavenging activity and cytotoxic activities against Doay and HEp-2 cell lines of these fractions were examined. The active fractions were further applied to purification by RP-HPLC, to obtain seven compounds, including a novel compound, serlyticin-A (1), together with six known compounds, serranticin (2), serratamolide A (3), thymine (4), (4-hydroxyphenyl)acetic acid (5), methyl p-hydroxybenzoate (6), and uracil (7). Their structures were determined by physical and extensive spectral analyses such as 1D and 2D NMR data, as well as comparison with literature values. Furthermore, the major secondary metabolites of EtOAc extract of the cultured supernatant were examined by the fingerprinting data of the HPLC system.
    關聯: Journal of Agricultural and Food Chemistry 60(36), pp.9043-9047
    DOI: 10.1021/jf302481n
    顯示於類別:[化學學系暨研究所] 期刊論文

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